教师简介
个人情况介绍、概览
张丽珊，女，博士研究生，讲师。主要从事基于组学研究肠道微生物的靶向药物。
人才称号、社会兼职等
无
主要研究方向
基于组学靶向肠道微生物筛选抗肿瘤药物
主持、参与的科研项目（含科研获奖等情况）
1. 国家自然科学基金面上项目，32171435，新型细菌去乙酰化酶AhCobQ的底物鉴定及其调控机制研究项目，2022.01-2025.12，58万元，在研，参与；
2. 福建省自然科学基金重点项目, 2020J02023,Fur蛋白K14位点酰基化修饰调控细菌耐药的机制研究, 2020.11-2023.11，30万元，在研，参与；
3.福建省自然科学基金面上项目, 2023J01165,嗜水气单胞菌LTTRs蛋白调控细菌生物膜耐药性的机制研究, 2023.01-2026.1,16万元，在研，参与；
近5年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：
[1] LS Zhang(张丽珊), YY Fu, QZ Xu, X Chen, YY Xie, BH Zhang, XM Lin*. Quantitative proteomics reveals the complex regulatory networks of LTTR-Type regulators in pleiotropic functions of Aeromonas hydrophila. International Journal of Biological Macromolecules, 2024: 132315. (第一作者，IF=7.7, JCR Q1)
[2] LS Zhang(张丽珊), LN Sun, R Srinivasan, MZ Lin, LQ Gong, XM Lin*. Unveiling a virulence-regulating mechanism in Aeromonas hydrophila: a quantitative exoproteomic analysis of an AraC-Like protein. Frontiers in Immunology, 2023, 14: 1191209. (第一作者，IF=5.7, JCR Q1)
[3] LS Zhang(张丽珊), ZJ Yao, HM Tang, QL Song, HH Song, JD Yao, Z Li, XF Xie, YX Lin, XM Lin*. The lysine acetylation modification in the porin Aha1 of Aeromonas hydrophila regulates the uptake of multi-drug antibiotics: molecular & Cellular Proteomics, 2022, 21:100248. (第一作者，IF=7, JCR Q1)
[4] LS Zhang#(张丽珊), Y Wu#, ZJ Yao, XY Wang, JZ Chen, WX Yang, JD Yao, YX Lin, Z Liu, XM Lin*. A high-throughput screening approach for bacterial quorum sensing inhibitors (QSIs) against Aeromonas hydrophila infection. Aquaculture, 2022, 560: 738488. (第一作者，IF=5.135, JCR Q1)
[5] LS Zhang#(张丽珊), XM Chen#, GB Wang, JD Yao, J Wei, Z Liu, XM Lin*, YL Liu*. Quantitative proteomics reveals the antibiotics adaptation mechanism of Aeromonas hydrophila under kanamycin stress. Journal of Proteomics, 2022, 264: 104621. (第一作者，IF=3.3, JCR Q2)
[6] LS Zhang(张丽珊), WX Li, LN Sun, YQ Wang, YX Lin, XM Lin*. Quantitative proteomics reveals the molecular mechanism of Aeromonas hydrophila in enoxacin stress. Journal of proteomics, 2020, 211: 103561. (第一作者，IF=4.044, JCR Q2)
[7] QL Song#, LS Zhang#(张丽珊), G Wang, HH Song, SZY Zhang, JD Yao, XM Lin*. Proteomics analysis reveals that CirA in Aeromonas hydrophila is involved in nutrient uptake. Environmental Microbiology, 2023,25(5): 977-989. (共同第一作者，IF=4.3, JCR Q2)
[8] ZQ Liu#, LS Zhang#(张丽珊), QL Song, HH Song, YQ Xu, JL Lu, QZ Xu, YZ Tang, YL Liu, GB Wang, XM Lin*. Quantitative proteomics reveal the inherent antibiotic resistance mechanism against norfloxacin resistance in Aeromonas hydrophila. Journal of Proteome Research, 2023, 22(4): 1193-1200. (共同第一作者，IF=3.8, JCR Q1)
[9] Z Li#, LS Zhang#(张丽珊), LN Sun, YQ Wang, JZ Chen, HM Tang, L Lin, XM Lin*. Proteomics analysis reveals the importance of transcriptional regulator slyA in regulation of several physiological functions in Aeromonas hydrophila. Journal of Proteomics, 2021, 244: 104275. (共同第一作者，IF=3.855, JCR Q2)
[10] YY Fu#, LS Zhang#(张丽珊), Y Lin, XR Chen, YC Zhong, WJ Jiang, XY Wu, XM Lin*. Unveiling the antibacterial mechanism of resveratrol against Aeromonas hydrophila through proteomics analysis. Frontiers in Cellular and Infection Microbiology,14: 1378094. (共同第一作者，IF=4.6, JCR Q1)
主编或参编的教材、专著
无
专利及其他
[1] 林向民，汪玉倩，张丽珊.一种细菌蛋白赖氨酸去乙酰化修饰酶及其应用.ZL202011467147.3
[2] 林向民，张丽珊,汪玉倩.一种新型蛋白赖氨酸去琥珀酰化修饰酶.ZL202310175626.5